Provide the student with basic information regarding the biological effects of ionizing radiation used in the medical field and frinish information on radiation protection standards with special reference to the dental field. Knowledge and ability to understand: upon completion of the course, the student should demonstrate knowledge and ability to understand the principles of radiobiology and radiation protection standards. Applied knowledge and ability to understand: at the end of the course the student should be able to correctly apply during dental practice the knowledge acquired in the field of radiobiology and radiation protection. Autonomy of judgment: at the end of the course, the student should demonstrate that he/she has not only acquired knowledge and concepts, but also be able to make appropriate judgments. Communication skills: upon completion of the course, the student should be able to express and argue appropriately through the specific terminology acquired from the lectures delivered, the material lecture and/or reference text. Learning skills: upon completion of the course, the student should demonstrate the ability to apply the minimum knowledge, skills and competencies described in this Syllabus.

Basic knowledge of chemistry and physics

- Properties of ionizing radiation; - Radiation effects at the molecular and subcellular level; - effects of radiation at the cellular level; - effects of radiation on tissues; - genetic effects of ionizing radiation; - factors modifying the biological effect of radiation; - radiobiology and clinical applications; - effects on complex biological systems; - radioinduced carcinogenesis; - human exposure to radiation; - radiation protection standards

Teaching material(slides). Giuseppe Guglielmi. Elementi di radiobiologia e radioprotezione. Piccin

-properties of ionizing radiation: radiophysics; radiochemistry; radio biochemistry; dose; fractionation and dose distribution; - effects of radiation at the molecular and subcellular levels: on proteins; on nucleic acids; on DNA and its synthesis; on nucleus, cytoplasm and cell membranes; - effects of radiation at the cellular level: cell death; curves of survival; target theory; radiosensitivity of the cellular cycle phases and of the synchronous cell populations; concept of recovery of the induced radio damage; - effects of radiation on tissues: radiosensitivity of tissues; death modality in mammals exposed to panirradiation (various syndromes); - genetic effects of ionizing radiation: chromosomal aberrations; genetic and chromosomal mutations; evaluation of genetic risks of radiation in humans; - factors that modify the biological effect of radiation: physical; chemical; organic; - radiobiology and clinical applications: fractionation in radiotherapy; - effects on complex biological systems: stochastic effects and graduated effects - radio induced carcinogenesis; - human exposure to radiation; - radiation protection standards.

lectures

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Oral examination: open questions to evaluate the knowledge and ability of the student's reasoning. The grade in thirtieths of this module concurs in the single final grade of the integrated course. The evaluation grid adopted is as follows: -Excellent (30 -30 cum laude): excellent knowledge of topics, expressed with appropriateness of specific language. The student(s) knows the basics of radiobiology and radiation protection. -Very good (27 -29): good knowledge of topics, expressed with appropriateness of specific language. The student/ess knows the basics of radiobiology and radiation protection. -Good (24-26): fair knowledge of topics, expressed with fair appropriateness of specific language. The student/ess knows the basics of radiobiology and radiation protection. -Sufficient (18-23): The student/ess does not show full knowledge of the topics covered of which he/she knows some basic aspects, satisfactory appropriateness of language, sufficient knowledge of the basics of radiobiology and radiation protection . -Insufficient (<18): The student/ess does not possess sufficient knowledge of the content of the program covered.

This course explores topics closely related to one or more goals of the United Nations 2030 Agenda for Sustainable Development (SDGs)