1. Knowledge and understanding: Know the preventive bases for emergencies (first fire rescue) in the workplace.
Knowing how an industrial toxic agent works and how to identify his presence in the workplace. Measure toxics in workplaces.
2. Applying knowledge and understanding to read and evaluate a safety data sheet in order to draw up a chemical risk assessment.
Know how some industrial toxicants act and how to prevent poisoning
3. Making judgements: be able to work avoiding occupational injuries and diseases
4. Communication skills: be able to communicate occupational hazards and understand related risks
5. Learning skills: be able to deepen arguments learned during the course, also looking to specific literature

PHARMACOLOGY
Introduction to Pharmacology. Pharmacokinetics. Absorption of drugs (routes of administration, bioavailability and bioequivalence). Drug distribution (volume of distribution, protein binding, drug
distribution in special districts). Biotransformation of drugs (phase 1 reactions, phase 2 reactions, enzyme inhibitors, enzyme inducers). Biliary excretion and enterohepatic circulation. Renal excretion of drugs and their metabolites. Elimination rate constant and half-life. Clearance. Drug interactions. Mechanisms of drug action at the cellular and molecular level. Receptors (drug-receptor interactions and quantitative response to medication, modulation of receptor responses ).
TOXICOLOGY Mechanisms of cell injury induced by toxins Mutagenesis and carcinogenesis Teratogenesis
Allergic reactions to drugs. Tolerance and dependence. Pharmacogenetics on some drug classes: Antimicrobials and hormones

INDUSTRIAL TOXICOLOGY General toxicology: kinetics: absorption, distribution, metabolism, elimination of toxic substances. Dynamics: dose and effect, adverse effect; graduated and non-graduable effects; dose-response relationship effects with threshold and without threshold; acute and chronic toxicity measures; non-effect derivative levels. Risk assessment: hazard identification, dose-response, classification and labeling, REACH, exposure definition, biological monitoring; risk characterization. Overview of risk management. Special toxicology: carbon monoxide; phosgene; formaldehyde; solvent, metals, PAH and dioxins toxicity. Industrial carcinogens IARC and EEC Classification. Emergencies in workplace regulations and prevention. First aid regulatory organization and prevention. Fire prevention.
IGIENE INDUSTRIALE II
Classification of chemical substances and safety data sheets. Methods of measuring pollutants in the workplace. Environmental and personal sampling and biological monitoring. Evaluation of measurements and ISO reference standards for sampling. Interpretation of results and comparison with occupational exposure limits. TLV and BEI. OEL.

Michelle A. Clark, Richard Finkel, Jose A. Rey, Karen Whalen
LE BASI DELLA FARMACOLOGIA
Seconda edizione italiana condotta sulla quinta edizione americana
G. Cornelio “La scatola nera- Appunti di tossicologia per la valutazione del rischio chimico. EUT, 2009
Alessio
e Apostoli: Manuale di Medicina del Lavoro e Igiene Industriale per Tecnici della Prevenzione, Piccin, 2009

PHARMACOLOGY
Introduction to Pharmacology. Pharmacokinetics. Absorption of drugs (routes of administration, bioavailability and bioequivalence). Drug distribution (volume of distribution, protein binding, drug
distribution in special districts). Biotransformation of drugs (phase 1 reactions, phase 2 reactions, enzyme inhibitors, enzyme inducers). Biliary excretion and enterohepatic circulation. Renal excretion of drugs and their metabolites. Elimination rate constant and half-life. Clearance. Drug interactions. Mechanisms of drug action at the cellular and molecular level. Receptors (drug-receptor interactions and quantitative response to medication, modulation of receptor responses ).
TOXICOLOGY Mechanisms of cell injury induced by toxins Mutagenesis and carcinogenesis Teratogenesis
Allergic reactions to drugs. Tolerance and dependence. Pharmacogenetics on some drug classes: Antimicrobials and hormones

INDUSTRIAL TOXICOLOGY General toxicology: kinetics: absorption, distribution, metabolism, elimination of toxic substances. Dynamics: dose and effect, adverse effect; graduated and non-graduable effects; dose-response relationship effects with threshold and without threshold; acute and chronic toxicity measures; non-effect derivative levels. Risk assessment: hazard identification, dose-response, classification and labeling, REACH, exposure definition, biological monitoring; risk characterization. Overview of risk management. Special toxicology: carbon monoxide; phosgene; formaldehyde; solvent, metals, PAH and dioxins toxicity. Industrial carcinogens IARC and EEC Classification. Emergencies in workplace regulations and prevention. First aid regulatory organization and prevention. Fire prevention.
IGIENE INDUSTRIALE II
Classification of chemical substances and safety data sheets. Methods of measuring pollutants in the workplace. Environmental and personal sampling and biological monitoring. Evaluation of measurements and ISO reference standards for sampling. Interpretation of results and comparison with occupational exposure limits. TLV and BEI. OEL.

lessons and cases studio

Slides and other material are available on the teams channel of the lessons

The evaluation of the student includes a written and/or oral test, possible tests in progress in which questions concerning the course program are proposed
The student must demonstrate that he has achieved the learning objectives of the course.
The exam score is attributed by means of a vote expressed out of thirty.
- Excellent (29, 30, 30 cum laude): excellent knowledge of the topics, excellent language skills, excellent analytical skills. Brilliant capability to recognize occupational diseases.
- Very good (26 - 28): good knowledge of the subjects, remarkable language proficiency, good analytical skills; more than good capability to recognize occupational diseases.
- Good (22-25): moderate knowledge of the main topics, good command of the language; moderate capability to recognize occupational diseases.
- Sufficient (18-21 minimal knowledge of the main teaching topics and technical language, limited ability to recognize occupational diseases.
- Insufficient: lack of acceptable knowledge of the contents of the different topics of the program.

Gender assessment of risks in healthcare professionals Assessment of risk factors for health and in the workplace