Learning and understanding the pathophysiology of internal medicine metabolic diseases, with particular regard to overweight and obesity, type 1 and type 2 diabetes mellitus, dyslipidemia. Students will be encouraged to appreciate connections between different diseases and underlying mechanisms, as well as fundamental connections between pahtophysiology and major clinical manifestations, as well as therapeutic approaches.

Knowledge of major biochemical pathways regulating intermediate metabolism.

Pathophysiology of overweight and obesity, diabetes mellitus and dyslipidemia, as well as their connections with clinical presentation and therapeutic strategies.

Lessons and slides

Energy balance, appetite regulation, energy expenditure, physical activity, mitochondrial function, brown adipose tissue, adiposopathy. Pathophysiology of obesity complications. Obesity treatment. Regulation of glucose metabolism and its derangements in diabetes mellitus. Pahtophysiology of type 1 and type 2 diabetes. Therapeutic approaches based on recent novel pathophysiological knowledge. Regulation of lipoprotein metabolism and its derangements. Dyslipidemias, their pathophysiology and related therapeutic principles.

Lessons and slides Harrison's Principles of Internal Medicine

There will be a single, integrated examination for the entire course of physiopathology, with a written part held via the moodle platform first (125 multiple-choice questions on 13 topics) in 2 hours and 33 minutes and then an oral part of 30 minutes. To be admitted to the oral part, it is necessary to have answered correctly to 60% of the questions and 60% of the topics. The oral exam will last 30 minutes and there will be 3 questions. As for the contents of this couse, there will be one oral question on one of the associations (10 minutes). Final score will be converted to a maximum of 30 points.
(30-30 cum laude=excellent knowledge; 27-29=very good knowledge; 24-26=good knowledge; 21-23 = just right knowledge; minimum amount of knowledge; <18= not enough knowledge)

This course explores topics closely related to one or more goals of the United Nations 2030 Agenda for Sustainable Development (SDGs)