Aim of the course is to offer to the students the knowledges and the skills to understand and recognize the main benign and malignant blood diseases and better understand the mechanisms of actions of new available treatments. The course will include an initial preparatory part on hemopoiesis and on the interpretation of blood cell count. Subsequently the course will focus on the pathophysiology, clinical presentation and laboratory of hereditary and acquired anemia. Similarly it will focus on to the different form of thrombocytopenia with particular regards to immune thrombocytopenia and thrombocytopenia associated microangiopathies. In this contest there will be a focus also on Aplastic anemia. The course then will focus on malignant hematologic diseases: chronic and acute leukemia, lymphomas, monoclonal gammopathies. The course will describe the main mechanisms of actions of treatments of specific hematologic diseases, focusing on new biologic or target therapies, on hemopoietic stem cell transplant and on the role of the modern cellular therapies.

Knowledges of biology, cytology, histology, physiology, biochemistry.

Etiology, patophysiology, clinical presentation, diagnostic workup, prognostic scores, general principles of therapy of the main benign and malignant blood diseases.

Slides presented in class. The slides will be uploaded in Teams and will be available to the students. Disease of blood and lymphopoietic organs. Sante Tura Esculapio.

• Blood, interpretation of blood cell count, hemopoiesis • Bone marrow biopsy • Hemopoietic stem cell sources and harvest • Classification of anemia • Iron deficiency anemia • Folate, cobalamin, megaloblastic anemia • Hereditary spherocytosis • Enzyme abnormalities anemia • Thalassemias • Sickle cell anemia • Classification of thrombocytopenia • Pseudo-thrombocytopenia • Immune thrombocytopenia • Thrombotic thrombocytopenic porpora and other microangiopathies • Heparin-induced thrombocytopenia • Aplastic anemia •Myeloproliferative neoplasms • Acute leukemias • Myelodisplastic neoplasms • Hemopoietic stem cell transplant • Lymphomas and lymphoid disorders • Plasma cell neoplasms

The students during classes will be educated on the epidemiology, pathophysiology, presentation, diagnosis and principle of therapy of the main blood diseases.

The students will have a written and oral test. Written test will be based on a multi choice quiz on topics discussed at lessons. Students who pass the written test will have an oral test that will allow to better understand the level of learning of the main blood diseases. The student must demonstrate that he/she is able to have acquired knowledge related to the diagnosis, physiopathological and prognostic framework of the pathologies treated during the course and have general principles of their treatment. The final score of the exam is assigned through a grade expressed in thirtieths that will take into account the result of the written test and the oral exam. The score assigned (from 18/30 to 30/30 with possible honors) will be an expression of the student's level of learning and the methods and completeness of presentation of the answers during the oral exam.

This course explores topics closely related to one or more goals of the United Nations 2030 Agenda for Sustainable Development (SDGs)